Searching for structures with analogs of Dovitinib.
Search results (23 entries covering 9 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FGFR4 | FGFR | TK | 4tyi | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 926 | 0.86 | |||
| FGFR1 | FGFR | TK | 5a46 | B | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3578 | 0.86 | ||
| STK10 (LOK) | STE20 | STE | 5owq | B | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 8387 | 0.86 | ||
| CHEK1 (CHK1) | CAMKL | CAMK | 2gdo | A | 4-[(3s)-1-azabicyclo[2.2.2]oct-3-ylamino]-3-(1h-benzimidazol-2-yl)-6-chloroquinolin-2(1h)-one | Human | 1606 | 0.41 | |||
| FGFR1 | FGFR | TK | 44ad | A | A | 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-3-yl]-6-(4-methylpiperazin-1-yl)-1~{h}-benzimidazole | Human | 15682 | 0.42 | ||
| FGFR1 | FGFR | TK | 5am7 | A | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3488 | 0.86 | ||
| FGFR1 | FGFR | TK | 44ad | A | B | 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-3-yl]-6-(4-methylpiperazin-1-yl)-1~{h}-benzimidazole | Human | 15672 | 0.42 | ||
| FGFR1 | FGFR | TK | 5am7 | A | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3533 | 0.86 | ||
| FGFR1 | FGFR | TK | 5a46 | B | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3526 | 0.86 | ||
| FGFR1 | FGFR | TK | 5am6 | B | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3521 | 0.86 | ||
| FGFR1 | FGFR | TK | 5am6 | A | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3494 | 0.86 | ||
| FGFR1 | FGFR | TK | 5am7 | B | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3531 | 0.86 | ||
| STK17B (DRAK2) | DAPK | CAMK | 7akg | A | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 13004 | 0.86 | ||
| STK10 (LOK) | STE20 | STE | 5owq | B | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 8389 | 0.86 | ||
| FGFR1 | FGFR | TK | 5am6 | B | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3587 | 0.86 | ||
| FGFR1 | FGFR | TK | 5a46 | A | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3505 | 0.86 | ||
| FGFR1 | FGFR | TK | 5am7 | B | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3588 | 0.86 | ||
| FGFR1 | FGFR | TK | 5am6 | A | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3514 | 0.86 | ||
| FGFR1 | FGFR | TK | 5a46 | A | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3532 | 0.86 | ||
| EIF2AK4 (GCN2) | PEK | Other | 7qq6 | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 14116 | 0.86 | |||
| STK17B (DRAK2) | DAPK | CAMK | 7akg | A | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 13005 | 0.86 | ||
| STK10 (LOK) | STE20 | STE | 5owq | A | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 8386 | 0.86 | ||
| STK10 (LOK) | STE20 | STE | 5owq | A | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 8385 | 0.86 |
Dovitinib
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