KLIFS - the structural kinase database

Searching for structures with analogs of Edecesertib.

Search results (15 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
IRAK4	IRAK	TKL	6lxy	D		n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide	Human	13161	0.42
IRAK4	IRAK	TKL	9pst	A		n-[(1r,4r)-4-(5-{(6p)-6-[(8r)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-4-[(propan-2-yl)amino]pyridin-3-yl}-1,3,4-thiadiazol-2-yl)cyclohexyl]acetamide	Human	15982	0.43
IRAK4	IRAK	TKL	8scv	A	B	6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide	Human	15973	0.53
IRAK4	IRAK	TKL	9na2	A		(6p)-6-[(8r)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-(methylamino)pyridine-3-carboxamide	Human	15974	0.82
IRAK4	IRAK	TKL	8scv	B	A	6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide	Human	15976	0.53
IRAK4	IRAK	TKL	9psu	A		n-[(1r,5s,8r)-3-(5-{(6p)-6-[(8s)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-4-[(propan-2-yl)amino]pyridin-3-yl}-1,3,4-thiadiazol-2-yl)-3-azabicyclo[3.2.1]octan-8-yl]acetamide	Human	15977	0.43
IRAK4	IRAK	TKL	8sce	A	A	n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-[(5-fluoropyrimidin-4-yl)amino]-4-[(propan-2-yl)amino]pyridine-3-carboxamide	Human	15983	0.41
IRAK4	IRAK	TKL	8scv	B	B	6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide	Human	15979	0.53
IRAK4	IRAK	TKL	9na6	A		(6p)-4-{[(1s)-1-cyanoethyl]amino}-6-[(8s)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-n-[(2s)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide	Human	15980	1.00
IRAK4	IRAK	TKL	8scv	A	A	6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide	Human	15981	0.53
IRAK4	IRAK	TKL	9pss	A		(7p,8s)-7-{(5m)-5-[1-(oxan-4-yl)-1h-1,2,3-triazol-4-yl]-4-[(propan-2-yl)amino]pyridin-2-yl}pyrrolo[1,2-b]pyridazine-3-carbonitrile	Human	15984	0.45
IRAK4	IRAK	TKL	8scw	A		(6m)-6-(5-cyano-1h-pyrazolo[3,4-b]pyridin-1-yl)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide	Human	15986	0.56
IRAK4	IRAK	TKL	8sce	A	B	n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-[(5-fluoropyrimidin-4-yl)amino]-4-[(propan-2-yl)amino]pyridine-3-carboxamide	Human	15987	0.41
IRAK4	IRAK	TKL	6lxy	E		n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide	Human	13162	0.42
IRAK4	IRAK	TKL	6lxy	B		n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide	Human	13163	0.42