KLIFS - the structural kinase database

Searching for structures with analogs of Exarafenib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
BRAF	RAF	TKL	8f7p	A	B	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	14702	0.51
BRAF	RAF	TKL	8f7p	A	A	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	14705	0.51
BRAF	RAF	TKL	6n0p	A	A	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	11597	0.51
BRAF	RAF	TKL	6n0p	A	B	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	11596	0.51
BRAF	RAF	TKL	6n0p	B	B	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	11595	0.51
BRAF	RAF	TKL	8qqg	A	A	(3~{s})-~{n}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{r})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamide	Human	15178	1.00
BRAF	RAF	TKL	8qqg	A	B	(3~{s})-~{n}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{r})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamide	Human	15179	1.00
MAPK14 (p38a)	MAPK	CMGC	3d83	A		n-{4'-[(cyclopropylmethyl)carbamoyl]-6-methylbiphenyl-3-yl}-2-morpholin-4-ylpyridine-4-carboxamide	Human	5028	0.47
BRAF	RAF	TKL	6n0p	B	A	n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide	Human	11594	0.51