Searching for structures with analogs of -.
Search results (17 entries covering 7 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EGFR | EGFR | TK | 3w2q | A | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 845 | 0.60 | ||
| EGFR | EGFR | TK | 4i23 | A | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 870 | 0.41 | |||
| EGFR | EGFR | TK | 2jiv | A | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 893 | 0.60 | ||
| ERBB4 (ErbB4) | EGFR | TK | 2r4b | B | B | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine | Human | 2823 | 0.40 | ||
| ERBB4 (ErbB4) | EGFR | TK | 2r4b | A | B | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine | Human | 2827 | 0.40 | ||
| ERBB4 (ErbB4) | EGFR | TK | 2r4b | B | A | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine | Human | 2818 | 0.40 | ||
| ERBB2 (ErbB2) | EGFR | TK | 7jxh | A | B | (2e)-n-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide | Human | 13887 | 0.58 | ||
| ERBB2 (ErbB2) | EGFR | TK | 7jxh | A | A | (2e)-n-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide | Human | 13888 | 0.58 | ||
| EGFR | EGFR | TK | 4i24 | A | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 831 | 0.41 | |||
| PKMYT1 (MYT1) | WEE | Other | 5vcw | B | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide | Human | 8346 | 0.77 | |||
| PKMYT1 (MYT1) | WEE | Other | 5vcw | A | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide | Human | 8335 | 0.77 | |||
| EGFR | EGFR | TK | 2jiv | B | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 812 | 0.60 | ||
| ERBB4 (ErbB4) | EGFR | TK | 2r4b | A | A | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine | Human | 2822 | 0.40 | ||
| EGFR | EGFR | TK | 3w2q | A | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 874 | 0.60 | ||
| EGFR | EGFR | TK | 2jiv | A | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 851 | 0.60 | ||
| EGFR | EGFR | TK | 4i24 | B | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 910 | 0.41 | |||
| EGFR | EGFR | TK | 2jiv | B | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 830 | 0.60 |
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