KLIFS - the structural kinase database

Searching for structures with analogs of Cevidoplenib.

Search results (17 entries covering 11 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
SYK	Syk	TK	6zcy	A	B	~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide	Human	13638	0.49
SYK	Syk	TK	8xq1	A		cyclopropyl-[5-[[4-[4-[[(3~{r},4~{s})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]-1-methyl-pyrrolo[2,3-b]pyridin-3-yl]methanone	Human	15580	0.69
SYK	Syk	TK	8xq2	A		cyclopropyl-[1-(2-fluoranylethyl)-5-[[4-[4-[[(3~{r},4~{s})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]indol-3-yl]methanone	Human	15581	0.67
SYK	Syk	TK	8xq0	A		cyclopropyl-[5-[[4-[4-[[(3~{s},4~{s})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]-1-methyl-indol-3-yl]methanone	Human	15582	0.78
SYK	Syk	TK	8wyw	A		ski-o-592	Human	15579	1.00
SYK	Syk	TK	6zcx	A	A	~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-piperidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide	Human	13642	0.48
SYK	Syk	TK	4rss	A	A	1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	6169	0.57
SYK	Syk	TK	4xg7	A	A	1-[(3-methyl-1-{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	6316	0.57
SYK	Syk	TK	4rss	A	B	1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	6170	0.57
SYK	Syk	TK	6zcy	A	A	~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide	Human	13634	0.49
SYK	Syk	TK	4xg8	C		1-[(1-{2-[(3-chloro-1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	6310	0.58
SYK	Syk	TK	6zcx	A	B	~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-piperidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide	Human	13637	0.48
SYK	Syk	TK	4xg9	B		1-[(1-{2-[(3-chloro-1,2-dimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	6315	0.55
SYK	Syk	TK	4xg9	A		1-[(1-{2-[(3-chloro-1,2-dimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	6311	0.55
SYK	Syk	TK	4xg6	A		1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	6312	0.50
SYK	Syk	TK	4xg8	A		1-[(1-{2-[(3-chloro-1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	6317	0.58
SYK	Syk	TK	4xg7	A	B	1-[(3-methyl-1-{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol	Human	6318	0.57