Searching for structures with analogs of Gunagratinib.
Search results (19 entries covering 9 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FGFR2 | FGFR | TK | 8w38 | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15403 | 0.65 | ||
| FGFR3 | FGFR | TK | 8udv | A | 3-[(6-chloro-1-cyclopropyl-1h-benzimidazol-5-yl)ethynyl]-1-[(3s,5s)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1h-pyrazole-4-carboxamide | Human | 15203 | 0.41 | |||
| FGFR2 | FGFR | TK | 8w2x | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]propan-1-one | Human | 15406 | 0.51 | |||
| FGFR2 | FGFR | TK | 8w3b | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15408 | 0.65 | ||
| FGFR2 | FGFR | TK | 8w3d | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15409 | 0.65 | ||
| FGFR3 | FGFR | TK | 8udu | A | B | 3-[(6-chloro-1-cyclopropyl-1h-benzimidazol-5-yl)ethynyl]-1-[(3s,5s)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1h-pyrazole-4-carboxamide | Human | 15204 | 0.41 | ||
| FGFR1 | FGFR | TK | 6mzw | B | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11165 | 0.65 | ||
| FGFR1 | FGFR | TK | 6mzq | B | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11171 | 0.65 | ||
| FGFR1 | FGFR | TK | 6mzw | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11157 | 0.65 | ||
| FGFR1 | FGFR | TK | 6mzq | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11156 | 0.65 | ||
| FGFR1 | FGFR | TK | 6mzw | B | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 10857 | 0.65 | ||
| FGFR1 | FGFR | TK | 6mzq | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 10860 | 0.65 | ||
| FGFR1 | FGFR | TK | 6mzw | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11162 | 0.65 | ||
| FGFR2 | FGFR | TK | 8w3d | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15410 | 0.65 | ||
| FGFR2 | FGFR | TK | 8w38 | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15411 | 0.65 | ||
| FGFR2 | FGFR | TK | 8w3b | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15412 | 0.65 | ||
| FGFR3 | FGFR | TK | 8udu | A | A | 3-[(6-chloro-1-cyclopropyl-1h-benzimidazol-5-yl)ethynyl]-1-[(3s,5s)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1h-pyrazole-4-carboxamide | Human | 15205 | 0.41 | ||
| FGFR3 | FGFR | TK | 8udt | A | 3-[(1-cyclopropyl-4,6-difluoro-1h-benzimidazol-5-yl)ethynyl]-1-[(3r,5r)-5-(methoxymethyl)-1-propanoylpyrrolidin-3-yl]-5-(methylamino)-1h-pyrazole-4-carboxamide | Human | 15206 | 0.40 | |||
| FGFR1 | FGFR | TK | 6mzq | B | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11161 | 0.65 |
Gunagratinib
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