Searching for structures with analogs of Amdizalisib.
Search results (7 entries covering 5 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PIK3CD (p110d) | PIK | Atypical | 5m6u | A | 4-azanyl-6-[[(1~{s})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile | Human | 9094 | 0.44 | |||
| PIK3CG (p110g) | PIK | Atypical | 5kae | A | 4-azanyl-6-[[(1~{s})-1-(6-fluoranyl-3-phenyl-4-piperazin-1-ylcarbonyl-quinolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile | Human | 9241 | 0.42 | |||
| Pik3cd (p110d) | PIK | Atypical | 5ncz | A | A | 4-azanyl-6-[[(1~{s})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile | Mouse | 9396 | 0.46 | ||
| Pik3cd (p110d) | PIK | Atypical | 5ncy | A | A | 4-azanyl-6-[[(1~{s})-1-(3-methyl-5-oxidanylidene-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile | Mouse | 9379 | 0.54 | ||
| PIK3CG (p110g) | PIK | Atypical | 5eds | A | 4-azanyl-6-[[(1~{s})-1-[6-fluoranyl-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile | Human | 9208 | 0.40 | |||
| Pik3cd (p110d) | PIK | Atypical | 5ncz | A | B | 4-azanyl-6-[[(1~{s})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile | Mouse | 9388 | 0.46 | ||
| Pik3cd (p110d) | PIK | Atypical | 5ncy | A | B | 4-azanyl-6-[[(1~{s})-1-(3-methyl-5-oxidanylidene-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile | Mouse | 9357 | 0.54 |
Amdizalisib
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