Searching for structures with analogs of Azenosertib.
Search results (65 entries covering 32 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SRC | Src | TK | 6e6e | E | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11479 | 0.42 | ||
| FGFR4 | FGFR | TK | 4qqc | A | B | n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide | Human | 932 | 0.42 | ||
| SRC | Src | TK | 6e6e | G | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11493 | 0.42 | ||
| EGFR | EGFR | TK | 5hg5 | A | A | n-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}propanamide | Human | 6375 | 0.40 | ||
| WEE1 (Wee1) | WEE | Other | 7n3u | A | 1-[(7r)-7-ethyl-7-hydroxy-7h-cyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 13857 | 0.77 | |||
| MAP2K7 | STE7 | STE | 6yg3 | A | A | n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide | Human | 12689 | 0.40 | ||
| WEE1 (Wee1) | WEE | Other | 9d0q | A | 1-[(6r)-6-(2,6-dichlorophenyl)-8-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]-7,8-dihydropteridin-5(6h)-yl]ethan-1-one | Human | 15664 | 0.40 | |||
| FGFR4 | FGFR | TK | 4qqc | A | A | n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide | Human | 934 | 0.42 | ||
| MAP2K7 | STE7 | STE | 6yg3 | A | B | n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide | Human | 12681 | 0.40 | ||
| WEE1 (Wee1) | WEE | Other | 5vda | A | 1-{6-[(1s)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9779 | 0.70 | |||
| SRC | Src | TK | 6ate | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10920 | 0.46 | |||
| MAPK1 (Erk2) | MAPK | CMGC | 6g54 | A | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10938 | 0.46 | ||
| EGFR | EGFR | TK | 5gmp | A | B | n-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | Human | 8168 | 0.41 | ||
| FGFR4 | FGFR | TK | 4qq5 | A | n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide | Human | 921 | 0.42 | |||
| PKMYT1 (MYT1) | WEE | Other | 5vd0 | A | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 8344 | 0.69 | |||
| SRC | Src | TK | 6e6e | E | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11478 | 0.42 | ||
| SRC | Src | TK | 6e6e | H | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11475 | 0.42 | ||
| SRC | Src | TK | 6e6e | E | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11490 | 0.42 | ||
| WEE1 (Wee1) | WEE | Other | 9r55 | A | mips-54859 | Human | 15666 | 0.41 | |||
| WEE1 (Wee1) | WEE | Other | 5vd8 | A | 6-{[3-chloro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9777 | 0.56 | |||
| WEE1 (Wee1) | WEE | Other | 5vd5 | A | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(morpholin-4-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9778 | 0.59 | |||
| WEE1 (Wee1) | WEE | Other | 5v5y | A | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 8328 | 0.69 | |||
| WEE1 (Wee1) | WEE | Other | 5vd7 | A | 6-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9782 | 0.56 | |||
| WEE1 (Wee1) | WEE | Other | 5vd4 | A | 6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1-{6-[(1s)-2,2,2-trifluoro-1-hydroxyethyl]pyridin-2-yl}-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9780 | 0.68 | |||
| WEE1 (Wee1) | WEE | Other | 8bju | A | A | 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one | Human | 14755 | 0.47 | ||
| MAP3K7 (TAK1) | MLK | TKL | 5j7s | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 7429 | 0.46 | |||
| MAP3K7 (TAK1) | MLK | TKL | 5e7r | A | 2-chloro-n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}acetamide | Human | 7412 | 0.41 | |||
| MAP3K7 (TAK1) | MLK | TKL | 5j9l | A | n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide | Human | 7426 | 0.40 | |||
| SRC | Src | TK | 6e6e | B | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11484 | 0.42 | ||
| SRC | Src | TK | 6e6e | B | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11476 | 0.42 | ||
| LCK | Src | TK | 3byo | A | 6-(2,6-dimethylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6h)-one | Human | 2272 | 0.46 | |||
| EGFR | EGFR | TK | 5gmp | A | A | n-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | Human | 8167 | 0.41 | ||
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | B | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10925 | 0.46 | ||
| EGFR | EGFR | TK | 9pwi | A | A | n-[2-({1-methyl-7-[4-(4-methylpiperazin-1-yl)anilino]-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl}methyl)phenyl]prop-2-enamide | Human | 16258 | 0.43 | ||
| PLK1 | PLK | Other | 8bjt | A | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 14712 | 0.69 | |||
| PLK1 | PLK | Other | 9d0p | A | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 15472 | 0.69 | |||
| MAP3K7 (TAK1) | MLK | TKL | 5jh6 | A | 2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoate | Human | 7427 | 0.44 | |||
| MAP3K7 (TAK1) | MLK | TKL | 5j8i | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 7428 | 0.44 | |||
| MAPK1 (Erk2) | MAPK | CMGC | 6g54 | A | B | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10937 | 0.46 | ||
| SRC | Src | TK | 6e6e | D | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11494 | 0.42 | ||
| SRC | Src | TK | 6e6e | F | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11487 | 0.42 | ||
| SRC | Src | TK | 6e6e | A | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11485 | 0.42 | ||
| SRC | Src | TK | 6e6e | H | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11481 | 0.42 | ||
| SRC | Src | TK | 6e6e | C | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11488 | 0.42 | ||
| SRC | Src | TK | 6e6e | G | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11477 | 0.42 | ||
| SRC | Src | TK | 6e6e | F | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11472 | 0.42 | ||
| SRC | Src | TK | 6e6e | D | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11489 | 0.42 | ||
| SRC | Src | TK | 6e6e | C | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11492 | 0.42 | ||
| SRC | Src | TK | 6e6e | H | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11483 | 0.42 | ||
| SRC | Src | TK | 6e6e | C | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11471 | 0.42 | ||
| SRC | Src | TK | 6e6e | D | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11473 | 0.42 | ||
| SRC | Src | TK | 6e6e | B | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11480 | 0.42 | ||
| SRC | Src | TK | 6e6e | F | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11486 | 0.42 | ||
| SRC | Src | TK | 6e6e | G | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11474 | 0.42 | ||
| SRC | Src | TK | 6e6e | A | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11491 | 0.42 | ||
| SRC | Src | TK | 6e6e | A | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11482 | 0.42 | ||
| WEE1 (Wee1) | WEE | Other | 9r56 | A | mips-54861 | Human | 15665 | 0.41 | |||
| WEE1 (Wee1) | WEE | Other | 5vd9 | A | 1-{6-[(1r)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9781 | 0.70 | |||
| WEE1 (Wee1) | WEE | Other | 8bju | A | B | 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one | Human | 14754 | 0.47 | ||
| EGFR | EGFR | TK | 9pwi | A | B | n-[2-({1-methyl-7-[4-(4-methylpiperazin-1-yl)anilino]-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl}methyl)phenyl]prop-2-enamide | Human | 16259 | 0.43 | ||
| EGFR | EGFR | TK | 5hg5 | A | B | n-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}propanamide | Human | 6376 | 0.40 | ||
| WEE2 (Wee1B) | WEE | Other | 5vdk | A | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 8349 | 0.69 | |||
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | A | B | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10926 | 0.46 | ||
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | A | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10923 | 0.46 | ||
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | B | B | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10924 | 0.46 |
Azenosertib
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