Searching for structures with analogs of Canertinib.
Search results (39 entries covering 28 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EGFR | EGFR | TK | 4i23 | A | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 870 | 0.60 | |||
| MET | Met | TK | 6sdc | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11532 | 0.42 | ||
| EGFR | EGFR | TK | 3ug2 | A | A | gefitinib | Human | 898 | 0.73 | ||
| STK10 (LOK) | STE20 | STE | 6i2y | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 10788 | 0.42 | |||
| EGFR | EGFR | TK | 4i24 | A | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 831 | 0.60 | |||
| EGFR | EGFR | TK | 4i22 | A | gefitinib | Human | 823 | 0.73 | |||
| EGFR | EGFR | TK | 2ity | A | gefitinib | Human | 790 | 0.73 | |||
| EGFR | EGFR | TK | 4wkq | A | A | gefitinib | Human | 889 | 0.73 | ||
| EGFR | EGFR | TK | 4wkq | A | B | gefitinib | Human | 837 | 0.73 | ||
| GAK | NAK | Other | 5y7z | B | gefitinib | Human | 10331 | 0.73 | |||
| ILK | MLK | TKL | 9d5h | A | gefitinib | Human | 15989 | 0.73 | |||
| ILK | MLK | TKL | 9d5e | A | gefitinib | Human | 15992 | 0.73 | |||
| EGFR | EGFR | TK | 2j5f | A | n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide | Human | 862 | 0.42 | |||
| EPHA2 (EphA2) | Eph | TK | 5ia4 | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7189 | 0.42 | ||
| EPHA2 (EphA2) | Eph | TK | 5ia4 | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7168 | 0.42 | ||
| EGFR | EGFR | TK | 3ug2 | A | B | gefitinib | Human | 819 | 0.73 | ||
| EGFR | EGFR | TK | 2ito | A | gefitinib | Human | 783 | 0.73 | |||
| EGFR | EGFR | TK | 2itz | A | gefitinib | Human | 789 | 0.73 | |||
| PKMYT1 (MYT1) | WEE | Other | 5vcw | B | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide | Human | 8346 | 0.43 | |||
| PKMYT1 (MYT1) | WEE | Other | 5vcw | A | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide | Human | 8335 | 0.43 | |||
| MAPK14 (p38a) | MAPK | CMGC | 4a9y | A | n-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamide | Human | 5073 | 0.42 | |||
| MAPK14 (p38a) | MAPK | CMGC | 2bak | A | n-(3-{[7-methoxy-6-(2-pyrrolidin-1-ylethoxy)quinazolin-4-yl]amino}-4-methylphenyl)-2-morpholin-4-ylisonicotinamide | Human | 5114 | 0.42 | |||
| EGFR | EGFR | TK | 5y25 | A | (2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide | Human | 10373 | 0.72 | |||
| EGFR | EGFR | TK | 4g5j | A | A | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 794 | 0.57 | ||
| EPHB4 (EphB4) | Eph | TK | 2vwu | A | n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine | Human | 370 | 0.46 | |||
| EGFR | EGFR | TK | 4g5p | A | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 809 | 0.57 | |||
| MET | Met | TK | 3lq8 | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 2998 | 0.42 | ||
| MET | Met | TK | 3lq8 | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 2964 | 0.42 | ||
| GAK | NAK | Other | 5y80 | A | A | gefitinib | Human | 10329 | 0.73 | ||
| GAK | NAK | Other | 5y80 | A | B | gefitinib | Human | 10330 | 0.73 | ||
| GAK | NAK | Other | 5y7z | A | gefitinib | Human | 10332 | 0.73 | |||
| EGFR | EGFR | TK | 9msr | A | n-[4-(3-chloro-2-fluoroanilino)-7-{[(1s,5r)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl]ethynyl}quinazolin-6-yl]-4-(morpholin-4-yl)butanamide | Human | 15868 | 0.45 | |||
| EGFR | EGFR | TK | 4g5j | A | B | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 852 | 0.57 | ||
| EGFR | EGFR | TK | 4i24 | B | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 910 | 0.60 | |||
| EGFR | EGFR | TK | 4lqm | A | n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide | Human | 785 | 0.42 | |||
| EGFR | EGFR | TK | 9os6 | A | canertinib | Human | 15893 | 1.00 | |||
| STK10 (LOK) | STE20 | STE | 6i2y | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 10787 | 0.42 | |||
| MET | Met | TK | 6sd9 | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11531 | 0.42 | |||
| MET | Met | TK | 6sdc | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11534 | 0.42 |
Canertinib
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