KLIFS - the structural kinase database

Searching for structures with analogs of Taletrectinib.

Search results (13 entries covering 7 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
DAPK3	DAPK	CAMK	3bqr	A	B	4-(6-{[(1r)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid	Human	386	0.40
ERN1 (IRE1)	IRE	Other	4z7h	A		2-methoxy-4-[6-(propan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide	Human	1794	0.45
PIM1	PIM	CAMK	2c3i	B	A	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	2348	0.40
ALK	ALK	TK	6edl	A	A	n-[(1s)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1h-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine	Human	11267	0.43
ERN1 (IRE1)	IRE	Other	4z7h	B		2-methoxy-4-[6-(propan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl]benzamide	Human	1801	0.45
DAPK3	DAPK	CAMK	3bqr	A	A	4-(6-{[(1r)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid	Human	380	0.40
PIM1	PIM	CAMK	2c3i	B	B	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	2374	0.40
CLK1	CLK	CMGC	6yta	A	B	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	12417	0.40
CLK1	CLK	CMGC	6yta	A	A	1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	12423	0.40
ACVR1 (ALK2)	STKR	TKL	4dym	A		1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone	Human	1509	0.40
ALK	ALK	TK	6edl	A	B	n-[(1s)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1h-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine	Human	11265	0.43
HASPIN (Haspin)	Haspin	Other	3f2n	A	B	(2s)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol	Human	3813	0.48
HASPIN (Haspin)	Haspin	Other	3f2n	A	A	(2s)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol	Human	3803	0.48