KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (28 entries covering 21 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	4i23	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	870	0.53
EGFR	EGFR	TK	3ug2	A	A	gefitinib	Human	898	0.43
EGFR	EGFR	TK	4i24	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	831	0.53
EGFR	EGFR	TK	4i22	A		gefitinib	Human	823	0.43
EGFR	EGFR	TK	2ity	A		gefitinib	Human	790	0.43
EGFR	EGFR	TK	4wkq	A	A	gefitinib	Human	889	0.43
EGFR	EGFR	TK	4wkq	A	B	gefitinib	Human	837	0.43
GAK	NAK	Other	5y7z	B		gefitinib	Human	10331	0.43
ILK	MLK	TKL	9d5h	A		gefitinib	Human	15989	0.43
ILK	MLK	TKL	9d5e	A		gefitinib	Human	15992	0.43
EGFR	EGFR	TK	2j5f	A		n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide	Human	862	0.42
EGFR	EGFR	TK	8hy7	A		~{n}-[3-[[6-fluoranyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide	Human	14941	0.40
EGFR	EGFR	TK	3ug2	A	B	gefitinib	Human	819	0.43
EGFR	EGFR	TK	2ito	A		gefitinib	Human	783	0.43
EGFR	EGFR	TK	2itz	A		gefitinib	Human	789	0.43
PKMYT1 (MYT1)	WEE	Other	5vcw	B		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide	Human	8346	0.40
PKMYT1 (MYT1)	WEE	Other	5vcw	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide	Human	8335	0.40
EGFR	EGFR	TK	5y25	A		(2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide	Human	10373	0.42
EGFR	EGFR	TK	4g5j	A	A	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	794	0.42
EGFR	EGFR	TK	4g5p	A		n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	809	0.42
GAK	NAK	Other	5y80	A	A	gefitinib	Human	10329	0.43
GAK	NAK	Other	5y80	A	B	gefitinib	Human	10330	0.43
GAK	NAK	Other	5y7z	A		gefitinib	Human	10332	0.43
EGFR	EGFR	TK	9msr	A		n-[4-(3-chloro-2-fluoroanilino)-7-{[(1s,5r)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl]ethynyl}quinazolin-6-yl]-4-(morpholin-4-yl)butanamide	Human	15868	0.40
EGFR	EGFR	TK	4g5j	A	B	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	852	0.42
EGFR	EGFR	TK	4i24	B		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	910	0.53
EGFR	EGFR	TK	4lqm	A		n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide	Human	785	0.42
EGFR	EGFR	TK	9os6	A		canertinib	Human	15893	0.58