Searching for structures with analogs of Falnidamol.
Search results (34 entries covering 20 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EGFR | EGFR | TK | 4i23 | A | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 870 | 0.40 | |||
| EGFR | EGFR | TK | 3ug2 | A | A | gefitinib | Human | 898 | 0.44 | ||
| EGFR | EGFR | TK | 4i24 | A | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 831 | 0.40 | |||
| EGFR | EGFR | TK | 4i22 | A | gefitinib | Human | 823 | 0.44 | |||
| EGFR | EGFR | TK | 2ity | A | gefitinib | Human | 790 | 0.44 | |||
| EGFR | EGFR | TK | 4wkq | A | A | gefitinib | Human | 889 | 0.44 | ||
| EGFR | EGFR | TK | 4wkq | A | B | gefitinib | Human | 837 | 0.44 | ||
| GAK | NAK | Other | 5y7z | B | gefitinib | Human | 10331 | 0.44 | |||
| ILK | MLK | TKL | 9d5h | A | gefitinib | Human | 15989 | 0.44 | |||
| ILK | MLK | TKL | 9d5e | A | gefitinib | Human | 15992 | 0.44 | |||
| EGFR | EGFR | TK | 3ug2 | A | B | gefitinib | Human | 819 | 0.44 | ||
| EGFR | EGFR | TK | 2ito | A | gefitinib | Human | 783 | 0.44 | |||
| EGFR | EGFR | TK | 2itz | A | gefitinib | Human | 789 | 0.44 | |||
| JAK2 | JakA | TK | 6vnh | B | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13342 | 0.42 | |||
| JAK2 | JakA | TK | 6vnf | B | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13346 | 0.40 | ||
| JAK2 | JakA | TK | 6vnf | A | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13347 | 0.40 | ||
| JAK2 | JakA | TK | 6vnl | D | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13297 | 0.44 | |||
| JAK2 | JakA | TK | 6vng | B | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13341 | 0.42 | |||
| JAK2 | JakA | TK | 6vnf | B | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13352 | 0.40 | ||
| EGFR | EGFR | TK | 4g5j | A | A | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 794 | 0.40 | ||
| EGFR | EGFR | TK | 4g5p | A | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 809 | 0.40 | |||
| JAK2 | JakA | TK | 6vnl | C | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13300 | 0.44 | |||
| JAK2 | JakA | TK | 6vng | A | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13358 | 0.42 | |||
| GAK | NAK | Other | 5y80 | A | A | gefitinib | Human | 10329 | 0.44 | ||
| GAK | NAK | Other | 5y80 | A | B | gefitinib | Human | 10330 | 0.44 | ||
| GAK | NAK | Other | 5y7z | A | gefitinib | Human | 10332 | 0.44 | |||
| JAK2 | JakA | TK | 6vnh | A | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13344 | 0.42 | |||
| JAK2 | JakA | TK | 6vni | A | 2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-1lambda~6~,2-thiazolidine-1,1-dione | Human | 13294 | 0.41 | |||
| JAK2 | JakA | TK | 6vnl | B | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13299 | 0.44 | |||
| JAK2 | JakA | TK | 6vnl | A | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13303 | 0.44 | |||
| JAK2 | JakA | TK | 6vnf | A | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13357 | 0.40 | ||
| EGFR | EGFR | TK | 4g5j | A | B | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 852 | 0.40 | ||
| EGFR | EGFR | TK | 4i24 | B | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 910 | 0.40 | |||
| EGFR | EGFR | TK | 9os6 | A | canertinib | Human | 15893 | 0.40 |
Falnidamol
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