Searching for structures with analogs of Mevociclib.
Search results (10 entries covering 7 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| EGFR | EGFR | TK | 4li5 | A | A | n-(3-{[5-chloro-4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide | Human | 841 | 0.44 | ||
| CDK12 (CRK7) | CDK | CMGC | 7nxk | A | (e)-n-[4-[(1r,3r)-3-[[5-chloranyl-4-(1h-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide | Human | 13547 | 0.67 | |||
| CDK13 (CHED) | CDK | CMGC | 7nxj | A | n-[4-[(3r)-3-[[5-chloranyl-4-(1h-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide | Human | 13544 | 0.52 | |||
| MAPK10 (JNK3) | MAPK | CMGC | 4x21 | A | n-ethyl-4-{[4-(1h-indol-3-yl)-5-iodopyrimidin-2-yl]amino}piperidine-1-carboxamide | Human | 6240 | 0.44 | |||
| EGFR | EGFR | TK | 4li5 | A | B | n-(3-{[5-chloro-4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide | Human | 797 | 0.44 | ||
| MAPK10 (JNK3) | MAPK | CMGC | 4x21 | B | n-ethyl-4-{[4-(1h-indol-3-yl)-5-iodopyrimidin-2-yl]amino}piperidine-1-carboxamide | Human | 6239 | 0.44 | |||
| MAPK10 (JNK3) | MAPK | CMGC | 2p33 | A | 4-{[5-chloro-4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-n-ethylpiperidine-1-carboxamide | Human | 3455 | 0.52 | |||
| CDK12 (CRK7) | CDK | CMGC | 5acb | D | n-[4-[(3r)-3-[[5-chloranyl-4-(1h-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide | Human | 6702 | 0.52 | |||
| CDK12 (CRK7) | CDK | CMGC | 5acb | C | n-[4-[(3r)-3-[[5-chloranyl-4-(1h-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide | Human | 6701 | 0.52 | |||
| CDK7 | CDK | CMGC | 6xd3 | J | n-(3-{[5-chloro-4-(1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)-4-{[4-(dimethylamino)butanoyl]amino}benzamide | Human | 12772 | 0.48 |
Mevociclib
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