Searching for structures with analogs of Semaxanib.
Search results (16 entries covering 8 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PIM1 | PIM | CAMK | 7qfm | A | A | 4-[(~{e})-(2-oxidanylidene-1~{h}-indol-3-ylidene)methyl]benzoic acid | Human | 14561 | 0.47 | ||
| PIM1 | PIM | CAMK | 7qfm | A | B | 4-[(~{e})-(2-oxidanylidene-1~{h}-indol-3-ylidene)methyl]benzoic acid | Human | 14560 | 0.47 | ||
| CAMKK2 (CaMKK2) | CAMKK | Other | 5yvc | A | 3-{2,4-dimethyl-5-[(z)-(2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl}propanoic acid | Human | 10754 | 0.52 | |||
| FGFR1 | FGFR | TK | 1fgi | A | A | 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone | Human | 3555 | 0.49 | ||
| Tbk1 (TBK1) | IKK | Other | 4jlc | A | 3-{2,4-dimethyl-5-[(z)-(2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl}propanoic acid | Mouse | 5698 | 0.52 | |||
| DYRK1A | DYRK | CMGC | 7a53 | A | B | (3~{e})-3-[(5-methylfuran-2-yl)methylidene]-1~{h}-indol-2-one | Human | 13741 | 0.53 | ||
| DYRK1A | DYRK | CMGC | 7a53 | A | A | (3~{e})-3-[(5-methylfuran-2-yl)methylidene]-1~{h}-indol-2-one | Human | 13755 | 0.53 | ||
| FGFR1 | FGFR | TK | 1fgi | B | A | 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone | Human | 3586 | 0.49 | ||
| FGFR1 | FGFR | TK | 1fgi | A | B | 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone | Human | 3552 | 0.49 | ||
| FGFR1 | FGFR | TK | 1fgi | B | B | 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone | Human | 3580 | 0.49 | ||
| RET | Ret | TK | 2x2m | A | (3z)-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3366 | 1.00 | |||
| RET | Ret | TK | 2x2m | B | (3z)-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3375 | 1.00 | |||
| RET | Ret | TK | 2x2k | A | B | (3z)-5-amino-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3358 | 0.71 | ||
| RET | Ret | TK | 2x2k | A | A | (3z)-5-amino-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3360 | 0.71 | ||
| NEK2 | NEK | Other | 2jav | A | B | 5-[(z)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 323 | 0.43 | ||
| NEK2 | NEK | Other | 2jav | A | A | 5-[(z)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 332 | 0.43 |
Semaxanib
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