Searching for structures with analogs of Ruboxistaurin.
Search results (28 entries covering 14 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PDPK1 (PDK1) | PDK1 | AGC | 3orz | A | B | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | Human | 3181 | 0.41 | ||
| PIM1 | PIM | CAMK | 1xws | A | A | 3-{1-[3-(dimethylamino)propyl]-1h-indol-3-yl}-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 2343 | 0.41 | ||
| PIM1 | PIM | CAMK | 2j2i | B | A | (9r)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9h,18h-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione | Human | 2318 | 1.00 | ||
| PDPK1 (PDK1) | PDK1 | AGC | 1uu3 | A | A | (9r)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9h,18h-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione | Human | 3180 | 1.00 | ||
| PRKCB (PKCb) | PKC | AGC | 9s9t | A | (9r)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9h,18h-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione | Human | 16135 | 1.00 | |||
| PIM1 | PIM | CAMK | 2j2i | B | B | (9r)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9h,18h-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione | Human | 2434 | 1.00 | ||
| PIM1 | PIM | CAMK | 1xws | A | B | 3-{1-[3-(dimethylamino)propyl]-1h-indol-3-yl}-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 2441 | 0.41 | ||
| PIM1 | PIM | CAMK | 2bik | B | B | 3-{1-[3-(dimethylamino)propyl]-1h-indol-3-yl}-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 2463 | 0.41 | ||
| PIM1 | PIM | CAMK | 2bil | B | 3-{1-[3-(dimethylamino)propyl]-1h-indol-3-yl}-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 2449 | 0.41 | |||
| PDPK1 (PDK1) | PDK1 | AGC | 3orz | D | B | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | Human | 3184 | 0.41 | ||
| PIM1 | PIM | CAMK | 2bik | B | A | 3-{1-[3-(dimethylamino)propyl]-1h-indol-3-yl}-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 2341 | 0.41 | ||
| PDPK1 (PDK1) | PDK1 | AGC | 1uu8 | A | B | 3-{1-[3-(dimethylamino)propyl]-1h-indol-3-yl}-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 3237 | 0.41 | ||
| DMPK (DMPK1) | DMPK | AGC | 2vd5 | A | 3-[1-(3-aminopropyl)-1h-indol-3-yl]-4-(1-methyl-1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 1901 | 0.41 | |||
| PDPK1 (PDK1) | PDK1 | AGC | 1uvr | A | 3-[1-(3-aminopropyl)-1h-indol-3-yl]-4-(1-methyl-1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 3193 | 0.41 | |||
| PDPK1 (PDK1) | PDK1 | AGC | 1uu7 | A | 3-(1h-indol-3-yl)-4-(1-{2-[(2s)-1-methylpyrrolidinyl]ethyl}-1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 3224 | 0.41 | |||
| PDPK1 (PDK1) | PDK1 | AGC | 3orz | B | A | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | Human | 3160 | 0.41 | ||
| PRKCI (PKCi) | PKC | AGC | 1zrz | A | 3-{1-[3-(dimethylamino)propyl]-1h-indol-3-yl}-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 3354 | 0.41 | |||
| DMPK (DMPK1) | DMPK | AGC | 2vd5 | B | 3-[1-(3-aminopropyl)-1h-indol-3-yl]-4-(1-methyl-1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 1902 | 0.41 | |||
| GSK3B | GSK | CMGC | 2ow3 | A | bis-(indole)maleimide pyridinophane | Human | 698 | 0.48 | |||
| GSK3B | GSK | CMGC | 2ow3 | B | bis-(indole)maleimide pyridinophane | Human | 649 | 0.48 | |||
| PDPK1 (PDK1) | PDK1 | AGC | 1uu3 | A | B | (9r)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9h,18h-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione | Human | 3248 | 1.00 | ||
| PDPK1 (PDK1) | PDK1 | AGC | 3orz | C | A | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | Human | 3150 | 0.41 | ||
| PDPK1 (PDK1) | PDK1 | AGC | 3orz | C | B | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | Human | 3243 | 0.41 | ||
| PDPK1 (PDK1) | PDK1 | AGC | 3orz | A | A | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | Human | 3197 | 0.41 | ||
| PDPK1 (PDK1) | PDK1 | AGC | 1uu8 | A | A | 3-{1-[3-(dimethylamino)propyl]-1h-indol-3-yl}-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione | Human | 3239 | 0.41 | ||
| PDPK1 (PDK1) | PDK1 | AGC | 3orz | D | A | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | Human | 3192 | 0.41 | ||
| PDPK1 (PDK1) | PDK1 | AGC | 3orz | B | B | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | Human | 3198 | 0.41 | ||
| PDPK1 (PDK1) | PDK1 | AGC | 3otu | A | 3-(1h-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1h-indol-3-yl}-1h-pyrrole-2,5-dione | Human | 3217 | 0.41 |
Ruboxistaurin
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