KLIFS - the structural kinase database

Searching for structures with analogs of Pimasertib.

Search results (12 entries covering 7 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MAP2K1	STE7	STE	6q0j	C	A	5-[(2-fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide	Human	11721	0.40
MAP2K1	STE7	STE	3eqc	A	A	2-[(2-chloro-4-iodophenyl)amino]-n-{[(2r)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide	Human	3280	0.42
MAP2K1	STE7	STE	6q0t	C	B	5-[(2-fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide	Human	11717	0.40
MAP2K1	STE7	STE	6q0j	C	B	5-[(2-fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide	Human	11713	0.40
MAP2K1	STE7	STE	6q0t	C	A	5-[(2-fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide	Human	11715	0.40
MAP2K1	STE7	STE	13dv	C		5-[(2-fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide	Human	16183	0.40
MAP2K2	STE7	STE	21oa	A		n-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[(2s)-2,3-dihydroxypropyl]cyclopropanesulfonamide	Human	16257	0.42
MAP2K1	STE7	STE	6q0j	D	B	5-[(2-fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide	Human	11718	0.40
MAP2K1	STE7	STE	3v04	A		4-[(2-fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)-1h-indazole-5-carboxamide	Human	3325	0.43
MAP2K1	STE7	STE	3eqc	A	B	2-[(2-chloro-4-iodophenyl)amino]-n-{[(2r)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide	Human	3300	0.42
MAP2K1	STE7	STE	6q0j	D	A	5-[(2-fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide	Human	11714	0.40
MAP2K1	STE7	STE	3v01	A		n-{[(2r)-2,3-dihydroxypropyl]oxy}-3-[(2-fluoro-4-iodophenyl)amino]furo[3,2-c]pyridine-2-carboxamide	Human	3291	0.52