KLIFS - the structural kinase database

Searching for structures with analogs of Abemaciclib.

Search results (11 entries covering 7 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
CDK4	CDK	CMGC	7sj3	A		n-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-amine	Human	14485	1.00
DYRK2	DYRK	CMGC	7ejv	B	B	[6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone	Human	14182	0.45
DYRK2	DYRK	CMGC	7ejv	B	A	[6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone	Human	14183	0.45
DYRK2	DYRK	CMGC	7ejv	A	B	[6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone	Human	14181	0.45
DYRK2	DYRK	CMGC	7ejv	A	A	[6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone	Human	14180	0.45
CDK6	CDK	CMGC	9d8u	A		atirmociclib	Human	15857	0.42
CDK6	CDK	CMGC	9pe7	A		(3r,4r)-4-({(4m)-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1h-1,3-benzimidazol-6-yl]pyrimidin-2-yl}amino)-1-(methanesulfonyl)piperidin-3-ol	Human	15858	0.54
CDK6	CDK	CMGC	5l2s	A		n-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-amine	Human	6990	1.00
DYRK1A	DYRK	CMGC	7o7k	A	A	n-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-amine	Human	13988	1.00
DYRK1A	DYRK	CMGC	7o7k	A	B	n-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-amine	Human	13987	1.00
HIPK3	DYRK	CMGC	7o7j	A		n-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-amine	Human	13997	1.00